Biopharmaceutics Classification System (BCS) Classification and Database -

Biopharmaceutics Classification System (BCS)

The BCS (Biopharmaceutics Classification System) was introduced in 1995 by Amidon et al., aiming to categorize drugs based on their solubility and permeability. The BCS was developed to help predict the in vivo behavior of pharmaceutical compounds, especially their absorption from oral dosage forms.

The primary goal of the BCS classification is to streamline drug development and regulatory processes by categorizing drugs based on two key factors:

Solubility
Permeability

BCS Classification

The BCS classification divides drugs into four categories based on their solubility and permeability properties:

Class I: High Solubility, High Permeability
- Drugs in this category dissolve well in water and can easily pass through biological membranes.
- These drugs typically exhibit good absorption and can be administered via conventional oral dosage forms like tablets or capsules.
Class II: Low Solubility, High Permeability
- These drugs have poor solubility in water but are absorbed well through biological membranes once they are dissolved.
- Formulations need to be designed to improve solubility (e.g., through the use of solubilizing agents or nanoparticles) to achieve sufficient bioavailability.

Class III: High Solubility, Low Permeability
- These drugs dissolve well in water but have limited ability to permeate biological membranes.
- For these drugs, enhancing permeability is the primary focus of formulation development (e.g., using permeability enhancers or new delivery systems).
Class IV: Low Solubility, Low Permeability
- Drugs in this class have both poor solubility and low permeability.
- These are the most challenging drugs to develop for oral administration and may require advanced formulations such as lipid-based systems, microspheres, or drug delivery technologies to enhance both solubility and permeability.

Biopharmaceutics Classification System (BCS) Searchable Database

S.No	Drug	Class	Therapeutic Area	Therapeutic Class	Indication (Uses)	Common Brand Names	Notes
1	Acetylsalicylic Acid (Aspirin)	BCS I	Cardiovascular	Antiplatelet, NSAID	Pain relief (headaches, muscle pain), fever reduction, inflammation, prevention of heart attack and stroke	Bayer Aspirin, Ecotrin, Bufferin	Low-dose aspirin is commonly used for secondary prevention of cardiovascular events due to blood-thinning effects.
2	Allopurinol	BCS I	Rheumatology	Xanthine Oxidase Inhibitor	Gout, hyperuricemia, prevention of kidney stones, uric acid buildup in chemotherapy	Zyloprim, Aloprim	Reduces uric acid production, preventing gout attacks and related complications.
3	Amantadine Hydrochloride	BCS I	Neurology, Infectious Diseases	Antiviral, Antiparkinsonian	Parkinson’s disease, influenza A (as antiviral), fatigue in multiple sclerosis	Symmetrel	Used for Parkinson’s disease and as an antiviral for influenza A, although resistance to influenza use has decreased.
4	Amitriptyline Hydrochloride	BCS I	Psychiatry, Neurology	Tricyclic Antidepressant (TCA)	Major depression, generalized anxiety, panic disorder, chronic pain, migraine prophylaxis	Elavil, Endep	Also used off-label for pain syndromes and anxiety disorders. Can cause sedation and anticholinergic side effects.
5	Amlodipine	BCS I	Cardiovascular	Calcium Channel Blocker (CCB)	Hypertension, Angina, Coronary artery disease	Norvasc	A long-acting calcium channel blocker that helps lower blood pressure and prevent chest pain (angina).
6	Amoxicillin	BCS I	Infectious Diseases	Antibiotic (Penicillin Class)	Bacterial infections (e.g., respiratory tract, urinary tract, ear infections)	Amoxil, Moxatag	Broad-spectrum antibiotic commonly prescribed for a variety of bacterial infections.
7	Ascorbic Acid	BCS I	General Health	Vitamin Supplement	Vitamin C deficiency, immune support, antioxidant properties	Vitamin C, Redoxon	Essential for collagen production, immune function, and as an antioxidant. Often used to prevent or treat scurvy.
8	Aspirin	BCS I	Cardiovascular	NSAID, Antiplatelet	Pain relief, inflammation, prevention of heart attack and stroke	Bayer, Ecotrin	As an antiplatelet, it is used to reduce the risk of heart attack and stroke by preventing blood clots.
9	Berotralstat	BCS I	Respiratory	Kallikrein Inhibitor	Hereditary Angioedema (HAE)	Orladeyo	A selective inhibitor of the kallikrein enzyme used for preventing HAE attacks.
10	Caffeine	BCS I	Central Nervous System	CNS Stimulant	Fatigue, migraine, respiratory stimulant	NoDoz, Vivarin	Used as a stimulant to alleviate fatigue and as a treatment for certain types of headaches (e.g., migraines).
11	Clindamycin	BCS I	Infectious Diseases	Antibiotic (Lincosamide)	Bacterial infections (e.g., skin infections, respiratory tract infections, acne)	Cleocin	An antibiotic commonly used for treating skin and soft tissue infections, as well as in acne treatment.
12	Diazepam	BCS I	Psychiatry	Benzodiazepine (Anxiolytic)	Anxiety, seizures, muscle spasms, alcohol withdrawal	Valium	A sedative that helps manage anxiety, muscle spasms, and seizures. Often used for short-term anxiety relief.
13	Diltiazem	BCS I	Cardiovascular	Calcium Channel Blocker (CCB)	Hypertension, angina, arrhythmia (atrial fibrillation)	Cardizem, Tiazac	A calcium channel blocker that helps reduce blood pressure and control certain types of arrhythmias.
14	Doxycycline Hydrochloride	BCS I	Infectious Diseases	Antibiotic (Tetracycline)	Bacterial infections (e.g., respiratory, urinary tract infections), acne, malaria	Vibramycin, Doryx	A tetracycline antibiotic used for a wide range of infections and as an acne treatment.
15	Ertugliflozin	BCS I	Endocrinology	Antidiabetic (SGLT2 Inhibitor)	Type 2 diabetes, chronic kidney disease	Steglatro	Used to improve blood sugar control in type 2 diabetes and to reduce the risk of kidney disease progression.
16	Escitalopram Oxalate	BCS I	Psychiatry	Antidepressant (SSRI)	Major depressive disorder, generalized anxiety disorder, panic disorder	Lexapro	A selective serotonin reuptake inhibitor (SSRI) that is used to treat depression and anxiety disorders.
17	Fluconazole	BCS I	Infectious Diseases	Antifungal	Fungal infections (e.g., candidiasis, cryptococcal meningitis)	Diflucan	Used to treat systemic and local fungal infections, especially in immunocompromised individuals.
18	Gliclazide	BCS I	Endocrinology	Antidiabetic (Sulfonylurea)	Type 2 diabetes management	Diamicron	A sulfonylurea that helps lower blood sugar levels in patients with type 2 diabetes by stimulating insulin release.
19	Imatinib	BCS I	Oncology	Anticancer (Tyrosine Kinase Inhibitor)	Chronic Myelogenous Leukemia (CML), Gastrointestinal Stromal Tumors (GIST)	Gleevec	A targeted cancer therapy used to treat CML and GIST by inhibiting the BCR-ABL fusion protein.
20	Itopride Hydrochloride	BCS I	Gastrointestinal	Prokinetic (GI Motility) Agent	Functional dyspepsia, gastroparesis	Ganaton	Used to improve gastrointestinal motility and relieve symptoms of bloating, nausea, and fullness.
21	Ketorolac Tromethamine	BCS I	Analgesic	Nonsteroidal Anti-inflammatory Drug (NSAID)	Acute pain, postoperative pain relief, short-term management of moderate pain	Toradol	Potent NSAID used for short-term management of pain. Not recommended for long-term use due to risks of gastrointestinal bleeding and kidney damage.
22	Levetiracetam	BCS I	Neurology	Antiepileptic (Seizure Treatment)	Seizure disorders (e.g., epilepsy)	Keppra	Commonly used for epilepsy and seizure control. Has a relatively favorable side-effect profile compared to other antiepileptic drugs.
23	Levofloxacin	BCS I	Infectious Diseases	Antibiotic (Fluoroquinolone)	Respiratory infections (e.g., pneumonia, bronchitis), urinary tract infections, skin infections	Levaquin	A fluoroquinolone antibiotic used for a variety of bacterial infections. Associated with risks of tendon rupture and QT prolongation.
24	Levodopa	BCS I	Neurology	Anti-Parkinson’s Dopamine Precursor	Parkinson’s disease, Parkinsonism	Sinemet	A mainstay treatment for Parkinson's disease, often combined with carbidopa to enhance its effectiveness and reduce side effects.
25	Levonorgestrel	BCS I	Reproductive Health	Contraceptive (Progestin)	Contraception, emergency contraception, hormone replacement therapy	Plan B, Next Choice	A synthetic progestin used in birth control and emergency contraception, also found in IUDs and certain hormonal pills.
26	Methimazole	BCS I	Endocrinology	Antithyroid	Hyperthyroidism (e.g., Graves' disease)	Tapazole	Inhibits thyroid hormone synthesis, commonly used to treat hyperthyroidism.
27	Metoprolol	BCS I	Cardiovascular	Beta-Blocker	Hypertension, heart failure, angina, arrhythmia, prevention of heart attack	Lopressor, Toprol XL	A cardioselective beta-blocker used for managing hypertension, arrhythmias, and heart failure.
28	Metronidazole	BCS I	Infectious Diseases	Antibiotic, Antiprotozoal	Bacterial infections (e.g., GI infections, vaginitis, skin infections), parasitic infections (e.g., giardiasis, amebiasis)	Flagyl	A broad-spectrum antibiotic and antiprotozoal medication. Commonly used for infections caused by anaerobic bacteria.
29	Mobocertinib	BCS I	Oncology	Anticancer (Tyrosine Kinase Inhibitor)	Non-small cell lung cancer (NSCLC) with EGFR mutations	Exkivity	A targeted cancer therapy for treating EGFR-mutant non-small cell lung cancer.
30	Norethisterone	BCS I	Reproductive Health	Progestin (Hormonal Therapy)	Contraception, menstrual disorders, endometriosis, treatment of abnormal uterine bleeding	Norlutin, Primolut N	A synthetic progestin used for contraception, hormone therapy, and treating menstrual irregularities.
31	Ofloxacin	BCS I	Infectious Diseases	Antibiotic (Fluoroquinolone)	Bacterial infections (e.g., urinary tract infections, respiratory infections)	Floxin	A fluoroquinolone antibiotic used for a range of bacterial infections.
32	Osilodrostat	BCS I	Endocrinology	11β-Hydroxylase Inhibitor	Cushing's syndrome	Isturisa	Used to treat Cushing's disease by inhibiting cortisol production.
33	Phenobarbital	BCS I	Neurology, Psychiatry	Antiepileptic (Barbiturate)	Seizure disorders, anxiety, insomnia, sedation	Luminal	A barbiturate used primarily for controlling seizures. Also used as a sedative, but its use is limited due to risk of dependence.
34	Prednisolone	BCS I	Immunology, Rheumatology	Corticosteroid (Anti-inflammatory)	Inflammatory conditions (e.g., arthritis, lupus), allergies, skin conditions	Orapred, Prelone	A corticosteroid used to treat a variety of inflammatory and autoimmune conditions.
35	Pregabalin	BCS I	Neurology, Pain Management	Anticonvulsant, Neuropathic Pain	Neuropathic pain, fibromyalgia, generalized anxiety disorder, seizures	Lyrica	Used for pain relief in conditions like diabetic neuropathy and fibromyalgia. Also used for seizure control and anxiety.
36	Promethazine Hydrochloride	BCS I	Psychiatry, Respiratory	Antihistamine (Anti-Allergy)	Allergies, nausea and vomiting, motion sickness, sedation	Phenergan	An antihistamine used for allergy relief, nausea prevention, and as a sedative.
37	Propranolol Hydrochloride	BCS I	Cardiovascular	Beta-Blocker (Cardiology, Anxiety)	Hypertension, arrhythmia, anxiety, migraine prophylaxis, heart failure	Inderal, InnoPran XL	A non-selective beta-blocker used for managing hypertension, heart arrhythmias, anxiety, and migraines.
38	Pyridoxine Hydrochloride	BCS I	Vitamin Supplementation	Vitamin Supplement	Vitamin B6 deficiency, morning sickness in pregnancy, peripheral neuropathy	Vitamin B6, Pyridoxal	A form of vitamin B6 used in treating deficiency and related conditions such as nausea in pregnancy.
39	Quetiapine Fumarate	BCS I	Psychiatry	Antipsychotic (Atypical)	Schizophrenia, bipolar disorder, depression, anxiety disorders	Seroquel	An atypical antipsychotic used for managing schizophrenia and bipolar disorder, and sometimes for insomnia or anxiety.
40	Riboflavin	BCS I	Vitamin Supplementation	Vitamin Supplement	Vitamin B2 deficiency, migraines (as a prophylactic)	Vitamin B2, Riboflavin	Used to prevent and treat vitamin B2 deficiency and often used in high doses for migraine prevention.
41	Ruxolitinib	BCS I	Oncology, Hematology	Anticancer (JAK Inhibitor)	Myelofibrosis, polycythemia vera, graft-versus-host disease	Jakafi	A targeted therapy used for blood cancers and conditions related to bone marrow dysfunction, such as myelofibrosis.
42	Salbutamol Sulfate	BCS I	Respiratory	Bronchodilator (Respiratory)	Asthma, chronic obstructive pulmonary disease (COPD), bronchospasm	Ventolin, Proventil	A short-acting bronchodilator used for immediate relief of asthma symptoms and chronic obstructive pulmonary disease (COPD).
43	Theophylline	BCS I	Respiratory	Bronchodilator (Respiratory)	Asthma, COPD, bronchospasm	Theo-24, Elixophyll	A bronchodilator used in asthma and COPD management. It works by relaxing the muscles in the lungs and expanding the air passages.
44	Timolol	BCS I	Cardiovascular, Ophthalmology	Beta-Blocker (Glaucoma, Hypertension)	Hypertension, glaucoma (ocular hypertension)	Timoptic, Betimol	A non-selective beta-blocker used for reducing intraocular pressure in glaucoma and managing hypertension.
45	Tramadol	BCS I	Pain Management	Opioid Analgesic (Pain Relief)	Moderate to severe pain, post-surgery pain, chronic pain syndromes	Ultram, Conzip, Ryzolt	A centrally acting analgesic used for moderate to severe pain, often in combination with other pain relievers. It has some potential for abuse.
46	Vildagliptin	BCS I	Endocrinology	Antidiabetic (DPP-4 Inhibitor)	Type 2 diabetes management, blood sugar control	Galvus	An oral diabetes medication that helps control blood sugar by increasing insulin release and decreasing glucagon secretion.
47	Voriconazole	BCS I	Infectious Diseases	Antifungal	Fungal infections (e.g., Aspergillus, Candida), invasive fungal infections	Vfend	A triazole antifungal used for treating serious, invasive fungal infections in immunocompromised individuals.
48	Zidovudine	BCS I	Infectious Diseases	Nucleoside Reverse Transcriptase Inhibitor (NRTI)	HIV infection (as part of combination therapy), prevention of maternal-fetal transmission	Retrovir	An antiretroviral used for the treatment and prevention of HIV infection. Typically used in combination with other medications for effective therapy.
49	Aceclofenac	BCS II	Pain Management, Rheumatology	NSAID	Pain, inflammation (e.g., rheumatoid arthritis, osteoarthritis)	Aceclofenac, Traxen	A non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation management, particularly in musculoskeletal disorders.
50	Asciminib	BCS II	Oncology, Hematology	Tyrosine Kinase Inhibitor	Chronic Myelogenous Leukemia (CML) with Philadelphia chromosome-positive	Scemblix	A novel drug for CML that inhibits the ABL kinase domain and has activity against resistant mutations of the disease.
51	Atorvastatin Calcium	BCS II	Cardiovascular	Statin (HMG-CoA Reductase Inhibitor)	Hyperlipidemia, prevention of cardiovascular disease, stroke prevention	Lipitor	A statin used to lower cholesterol levels and reduce the risk of cardiovascular events, such as heart attack and stroke.
52	Budesonide	BCS II	Respiratory, Gastroenterology	Corticosteroid	Asthma, COPD, inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis	Pulmicort, Entocort, Uceris	A corticosteroid used for controlling asthma, Crohn's disease, and ulcerative colitis by reducing inflammation.
53	Cefuroxime	BCS II	Infectious Diseases	Antibiotic (Cephalosporin)	Respiratory infections, urinary tract infections, skin infections	Ceftin, Zinacef	A second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
54	Chlorzoxazone	BCS II	Musculoskeletal Disorders	Muscle Relaxant	Muscle spasms, muscle pain, spasticity	Parafon Forte, Lorzone	A muscle relaxant used to relieve muscle spasms and discomfort, often in conjunction with physical therapy.
55	Clonazepam	BCS II	Neurology, Psychiatry	Benzodiazepine	Seizure disorders (e.g., epilepsy), panic disorders, anxiety	Klonopin	A benzodiazepine used for managing seizures and panic disorder. It has a long half-life, making it effective for seizure control.
56	Clopidogrel	BCS II	Cardiovascular	Antiplatelet	Prevention of blood clots (e.g., after heart attack or stroke), coronary artery disease	Plavix	An antiplatelet medication used to reduce the risk of stroke, heart attack, and other vascular events in high-risk patients.
57	Clozapine	BCS II	Psychiatry	Atypical Antipsychotic	Schizophrenia, treatment-resistant schizophrenia	Clozaril, FazaClo	An atypical antipsychotic used in schizophrenia that can be effective when other antipsychotics fail, though it has significant side effects (e.g., agranulocytosis).
58	Daclatasvir	BCS II	Infectious Diseases	Antiviral (NS5A Inhibitor)	Hepatitis C virus (HCV) infection	Daklinza	A direct-acting antiviral used in combination with other medications for the treatment of hepatitis C infection.
59	Danazol	BCS II	Endocrinology, Gynecology	Synthetic Androgen	Endometriosis, fibrocystic breast disease, hereditary angioedema	Danocrine	A synthetic steroid used to treat endometriosis and reduce symptoms of fibrocystic breast disease, also used in treating hereditary angioedema.
60	Dexlansoprazole	BCS II	Gastroenterology	Proton Pump Inhibitor (PPI)	Gastroesophageal reflux disease (GERD), erosive esophagitis	Dexilant	A proton pump inhibitor (PPI) used to treat GERD, heartburn, and damage caused by acid reflux.
61	Dextromethorphan Hydrobromide	BCS II	Respiratory	Antitussive (Cough Suppressant)	Cough due to common cold, flu, or other respiratory conditions	Delsym, Robitussin DM	A cough suppressant used to treat dry, persistent coughs, typically in combination with other cold medications.
62	Diacerin	BCS II	Rheumatology	Anti-inflammatory, Disease-Modifying Antirheumatic Drug (DMARD)	Osteoarthritis, pain, inflammation	Artz	A disease-modifying drug used in the treatment of osteoarthritis to reduce pain and inflammation.
63	Diclofenac Sodium	BCS II	Pain Management, Rheumatology	NSAID	Pain, inflammation (e.g., arthritis, osteoarthritis, muscle injuries)	Voltaren, Cataflam	A potent NSAID used for pain and inflammation relief, commonly in joint and musculoskeletal disorders.
64	Dolutegravir Sodium	BCS II	Infectious Diseases	Integrase Inhibitor	HIV infection (used in combination with other antiretrovirals)	Tivicay	An antiretroviral drug used as part of combination therapy for the treatment of HIV.
65	Efavirenz	BCS II	Infectious Diseases	Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)	HIV infection (part of combination therapy)	Sustiva, Stocrin	An antiretroviral used to treat HIV, often used in combination with other antiretroviral drugs. Known for potential neuropsychiatric side effects.
66	Enzalutamide	BCS II	Oncology	Androgen Receptor Inhibitor	Prostate cancer (metastatic castration-resistant)	Xtandi	A treatment for metastatic castration-resistant prostate cancer that inhibits androgen receptor signaling.
67	Eplerenone	BCS II	Cardiovascular	Aldosterone Antagonist	Heart failure, hypertension, post-myocardial infarction	Inspra	An aldosterone antagonist used to manage heart failure and hypertension, helping reduce fluid retention and blood pressure.
68	Etoricoxib	BCS II	Pain Management, Rheumatology	NSAID	Pain, inflammation (e.g., osteoarthritis, rheumatoid arthritis, ankylosing spondylitis)	Arcoxia	A selective COX-2 inhibitor NSAID used for pain and inflammation, with less gastrointestinal side effects compared to non-selective NSAIDs.
69	Felodipine	BCS II	Cardiovascular	Calcium Channel Blocker	Hypertension, angina	Plendil	A calcium channel blocker used for managing high blood pressure and preventing angina (chest pain).
70	Fenofibrate	BCS II	Cardiovascular, Lipid Disorders	Fibrate	Hyperlipidemia, dyslipidemia, hypertriglyceridemia	Tricor, Lipofen	A fibrate used to lower cholesterol and triglycerides in patients at risk of cardiovascular disease.
71	Gefitinib	BCS II	Oncology	Tyrosine Kinase Inhibitor	Non-small cell lung cancer (NSCLC) with EGFR mutations	Iressa	A targeted therapy for NSCLC that inhibits the epidermal growth factor receptor (EGFR) to prevent cancer cell proliferation.
72	Ibrutinib	BCS II	Oncology, Hematology	Bruton's Tyrosine Kinase (BTK) Inhibitor	Chronic lymphocytic leukemia (CLL), mantle cell lymphoma, Waldenström's macroglobulinemia	Imbruvica	A targeted therapy used to treat various blood cancers by inhibiting BTK, which is essential for B-cell receptor signaling in cancerous B cells.
73	Ibuprofen	BCS II	Pain Management, Inflammation	NSAID	Pain relief, fever reduction, inflammation (e.g., arthritis, menstrual pain, headaches)	Advil, Motrin	A widely used over-the-counter NSAID for pain, inflammation, and fever management.
74	Indinavir Sulfate	BCS II	Infectious Diseases	Protease Inhibitor	HIV infection (part of combination therapy)	Crixivan	A protease inhibitor used in combination with other HIV drugs for treating HIV infection. Now less commonly used due to newer agents with fewer side effects.
75	Ketoprofen	BCS II	Pain Management, Inflammation	NSAID	Pain, inflammation (e.g., arthritis, soft tissue injuries, dysmenorrhea)	Orudis, Actron	An NSAID used for the management of pain and inflammation, including conditions like arthritis and menstrual cramps.
76	Ivermectin	BCS II	Infectious Diseases	Anthelmintic, Antiprotozoal	Parasitic infections (e.g., scabies, onchocerciasis, lymphatic filariasis)	Stromectol	Used for treating a variety of parasitic infections, especially in tropical and developing countries.
77	Lansoprazole	BCS II	Gastroenterology	Proton Pump Inhibitor (PPI)	GERD, peptic ulcers, Zollinger-Ellison syndrome	Prevacid	A proton pump inhibitor used for treating acid-related stomach conditions, including GERD and ulcers.
78	Mebendazole	BCS II	Infectious Diseases	Anthelmintic	Parasitic worm infections (e.g., pinworm, hookworm, roundworm, whipworm)	Vermox	An anthelmintic drug used to treat intestinal worm infections.
79	Montelukast Sodium	BCS II	Respiratory, Allergy	Leukotriene Receptor Antagonist	Asthma, allergic rhinitis, exercise-induced bronchoconstriction	Singulair	A leukotriene receptor antagonist used for managing asthma and allergy symptoms.
80	Naproxen	BCS II	Pain Management, Inflammation	NSAID	Pain, inflammation (e.g., arthritis, musculoskeletal pain, menstrual cramps)	Aleve, Naprosyn	A non-selective NSAID used to reduce pain, inflammation, and fever, with a longer half-life than ibuprofen.
81	Nicardipine	BCS II	Cardiovascular	Calcium Channel Blocker	Hypertension, angina	Cardene	A calcium channel blocker used to manage high blood pressure and chest pain.
82	Nitrofurantoin	BCS II	Infectious Diseases	Antibiotic	Urinary tract infections	Macrobid, Furadantin	An antibiotic used to treat and prevent urinary tract infections caused by specific bacteria.
83	Obeticholic Acid	BCS II	Hepatology	Farnesoid X Receptor Agonist	Primary biliary cholangitis (PBC), nonalcoholic steatohepatitis (NASH)	Ocaliva	A treatment for liver diseases such as PBC and NASH, by activating the farnesoid X receptor to reduce liver inflammation and fibrosis.
84	Olanzapine	BCS II	Psychiatry, Neurology	Atypical Antipsychotic	Schizophrenia, bipolar disorder, agitation, treatment-resistant depression	Zyprexa	An atypical antipsychotic used for managing schizophrenia and bipolar disorder, also for short-term treatment of agitation in psychiatric patients.
85	Omeprazole	BCS II	Gastroenterology	Proton Pump Inhibitor (PPI)	GERD, peptic ulcers, Zollinger-Ellison syndrome	Prilosec, Losec	A PPI used to treat acid-related stomach conditions such as GERD, ulcers, and acid reflux.
86	Oxcarbazepine	BCS II	Neurology	Anticonvulsant	Epilepsy, partial seizures, trigeminal neuralgia	Trileptal	A newer anticonvulsant used for the treatment of partial seizures and sometimes for trigeminal neuralgia.
87	Ozanimod	BCS II	Immunology, Neurology	Sphingosine-1-Phosphate Receptor Modulator	Multiple sclerosis, ulcerative colitis	Zeposia	A medication used for multiple sclerosis and ulcerative colitis by modulating immune cell movement and reducing inflammation.
88	Palbociclib Isethionate	BCS II	Oncology	CDK4/6 Inhibitor	Breast cancer (HR-positive, HER2-negative, metastatic)	Ibrance	A targeted cancer therapy used in combination with hormonal therapy for HR-positive breast cancer.
89	Paliperidone	BCS II	Psychiatry	Atypical Antipsychotic	Schizophrenia, schizoaffective disorder	Invega	An atypical antipsychotic used for treating schizophrenia and schizoaffective disorder, a metabolite of risperidone.
90	Pemigatinib	BCS II	Oncology	Fibroblast Growth Factor Receptor (FGFR) Inhibitor	Cholangiocarcinoma (bile duct cancer)	Pemazyre	A targeted therapy used to treat cholangiocarcinoma with FGFR2 gene fusions.
91	Phenytoin Sodium	BCS II	Neurology	Anticonvulsant	Seizure disorders (e.g., epilepsy, status epilepticus)	Dilantin, Phenytek	An anticonvulsant used to control various types of seizures, but requires monitoring due to narrow therapeutic index.
92	Posaconazole	BCS II	Infectious Diseases	Antifungal	Fungal infections, especially in immunocompromised patients	Noxafil	A triazole antifungal used for invasive fungal infections, including Aspergillus, Candida, and Zygomycetes.
93	Pralsetinib	BCS II	Oncology	Tyrosine Kinase Inhibitor	Non-small cell lung cancer (NSCLC) with RET fusion mutations	Gavreto	A targeted therapy for lung cancer with RET gene fusions, inhibiting the RET kinase and blocking tumor growth.
94	Racecadotril	BCS II	Gastroenterology	Antidiarrheal	Acute diarrhea, especially in children and infants	Hidrasec	An antidiarrheal agent that works by reducing the secretion of fluids in the intestines, providing symptomatic relief from diarrhea.
95	Rifampicin	BCS II	Infectious Diseases	Antibiotic (Rifamycin Derivative)	Tuberculosis, leprosy, meningococcal infections	Rifadin	A key antibiotic used for tuberculosis treatment, often in combination with other agents to prevent resistance.
96	Risperidone	BCS II	Psychiatry	Atypical Antipsychotic	Schizophrenia, bipolar disorder, irritability in autism	Risperdal	An atypical antipsychotic used to treat schizophrenia, bipolar disorder, and other conditions with mood stabilization properties.
97	Rosuvastatin	BCS II	Cardiovascular	Statin (HMG-CoA Reductase Inhibitor)	Hyperlipidemia, prevention of cardiovascular events, stroke prevention	Crestor	A statin used to lower cholesterol and reduce the risk of heart attack and stroke by reducing low-density lipoprotein (LDL) levels.
98	Sertraline Hydrochloride	BCS II	Psychiatry	Selective Serotonin Reuptake Inhibitor (SSRI)	Depression, anxiety disorders, obsessive-compulsive disorder (OCD), PTSD	Zoloft	An SSRI used primarily for the treatment of depression and anxiety disorders by increasing serotonin levels in the brain.
99	Sildenafil	BCS II	Cardiovascular, Urology	Phosphodiesterase Type 5 Inhibitor	Erectile dysfunction, pulmonary arterial hypertension	Viagra, Revatio	A PDE5 inhibitor commonly used for erectile dysfunction and pulmonary hypertension by increasing blood flow to the penis and relaxing blood vessels.
100	Spironolactone	BCS II	Cardiovascular, Endocrinology	Aldosterone Antagonist	Heart failure, hypertension, primary hyperaldosteronism, edema, acne, hirsutism	Aldactone	An aldosterone antagonist used to treat heart failure and high blood pressure, also used in conditions like acne and excessive hair growth (hirsutism).
101	Sulfamethoxazole	BCS II	Infectious Diseases	Antibiotic (Sulfonamide)	Bacterial infections (e.g., urinary tract infections, respiratory infections)	Bactrim, Septra	A sulfonamide antibiotic often combined with trimethoprim to treat a variety of bacterial infections.
102	Tamoxifen Citrate	BCS II	Oncology, Endocrinology	Selective Estrogen Receptor Modulator (SERM)	Breast cancer (estrogen receptor-positive), prevention of breast cancer recurrence	Nolvadex	A SERM used to treat estrogen receptor-positive breast cancer and to reduce the risk of breast cancer recurrence.
103	Telmisartan	BCS II	Cardiovascular	Angiotensin II Receptor Blocker (ARB)	Hypertension, prevention of cardiovascular events (e.g., stroke, heart attack)	Micardis	An ARB used to treat high blood pressure and reduce the risk of heart attack, stroke, and kidney complications in certain populations.
104	Terbinafine Hydrochloride	BCS II	Infectious Diseases	Antifungal	Fungal infections (e.g., athlete’s foot, ringworm, onychomycosis)	Lamisil	An antifungal used topically or orally for treating fungal infections like athlete’s foot, nail infections, and ringworm.
105	Trimethoprim	BCS II	Infectious Diseases	Antibiotic (Antifolate)	Bacterial infections, urinary tract infections (often combined with sulfamethoxazole)	Bactrim, Septra	An antibiotic used primarily for urinary tract infections and often combined with sulfamethoxazole to increase efficacy.
106	Valsartan	BCS II	Cardiovascular	Angiotensin II Receptor Blocker (ARB)	Hypertension, heart failure, prevention of cardiovascular events	Diovan	An ARB used to treat high blood pressure and heart failure, and to reduce the risk of death after a heart attack.
107	Venetoclax	BCS II	Oncology	BCL-2 Inhibitor	Chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML)	Venclexta	A targeted cancer therapy that works by inhibiting BCL-2, a protein that prevents apoptosis, allowing cancer cells to survive.
108	Vericiguat	BCS II	Cardiovascular	Soluble Guanylate Cyclase (sGC) Stimulator	Heart failure with reduced ejection fraction (HFrEF)	Verquvo	A medication used to treat heart failure by stimulating soluble guanylate cyclase to increase cyclic GMP and improve heart function.
109	Abacavir	BCS III	Infectious Diseases	Nucleoside Reverse Transcriptase Inhibitor (NRTI)	HIV infection (as part of combination therapy)	Ziagen	An NRTI used for treating HIV infection, often combined with other antiretroviral drugs as part of a regimen.
110	Acyclovir	BCS III	Infectious Diseases	Antiviral (Nucleoside Analog)	Herpes simplex virus infections, varicella-zoster virus infections (shingles)	Zovirax	An antiviral used for the treatment of herpes virus infections, including cold sores, shingles, and chickenpox.
111	Atenolol	BCS III	Cardiovascular	Beta-blocker	Hypertension, angina, prevention of heart attack	Tenormin	A beta-blocker used to treat high blood pressure, chest pain, and to reduce the risk of heart attack and stroke.
112	Baclofen	BCS III	Neurology, Musculoskeletal	Muscle Relaxant	Muscle spasticity (e.g., from multiple sclerosis, spinal cord injuries)	Lioresal	A muscle relaxant used to treat spasticity and muscle stiffness in conditions such as multiple sclerosis and spinal cord injury.
113	Benznidazole	BCS III	Infectious Diseases	Antiprotozoal	Chagas disease (Trypanosoma cruzi infection)	Roche (no commercial brand)	An antiprotozoal used to treat Chagas disease caused by Trypanosoma cruzi, typically in the early stages of infection.
114	Chloramphenicol	BCS III	Infectious Diseases	Antibiotic (Amphenicol)	Bacterial infections (e.g., meningitis, typhoid fever)	Chloromycetin	A broad-spectrum antibiotic used for serious bacterial infections, typically reserved for severe cases due to its side effect profile.
115	Cimetidine	BCS III	Gastroenterology	H2 Receptor Antagonist	GERD, peptic ulcers, Zollinger-Ellison syndrome	Tagamet	A histamine H2 receptor antagonist used to reduce stomach acid, treat GERD, ulcers, and Zollinger-Ellison syndrome.
116	Dapagliflozin	BCS III	Endocrinology, Cardiovascular	SGLT-2 Inhibitor	Type 2 diabetes, heart failure, chronic kidney disease	Farxiga	An SGLT2 inhibitor used for managing type 2 diabetes, heart failure with reduced ejection fraction (HFrEF), and chronic kidney disease.
117	Empagliflozin	BCS III	Endocrinology, Cardiovascular	SGLT-2 Inhibitor	Type 2 diabetes, heart failure, chronic kidney disease	Jardiance	An SGLT2 inhibitor used to lower blood sugar in type 2 diabetes and also reduce heart failure symptoms and improve kidney function.
118	Ergocalciferol	BCS III	Endocrinology, Bone Health	Vitamin D Analog	Vitamin D deficiency, rickets, osteomalacia, osteoporosis	Drisdol, Calciferol	A form of vitamin D used to treat and prevent bone disorders caused by vitamin D deficiency.
119	Famotidine	BCS III	Gastroenterology	H2 Receptor Antagonist	GERD, peptic ulcers, Zollinger-Ellison syndrome	Pepcid	A second-generation H2 receptor antagonist used to reduce stomach acid and treat conditions like GERD and ulcers.
120	Fexinidazole	BCS III	Infectious Diseases	Antiprotozoal	Sleeping sickness (African trypanosomiasis)	Lampit	An antiparasitic used to treat African sleeping sickness caused by Trypanosoma brucei.
121	Fosfomycin	BCS III	Infectious Diseases	Antibiotic	Urinary tract infections (UTIs)	Monurol	An antibiotic used primarily for the treatment of uncomplicated urinary tract infections (UTIs).
122	Gabapentin	BCS III	Neurology, Pain Management	Anticonvulsant, Analgesic	Seizures, neuropathic pain, restless leg syndrome	Neurontin, Gralise	An anticonvulsant and nerve pain medication used for conditions like epilepsy, diabetic neuropathy, and fibromyalgia.
123	Lamivudine	BCS III	Infectious Diseases	Nucleoside Reverse Transcriptase Inhibitor (NRTI)	HIV infection, chronic hepatitis B	Epivir, 3TC	An NRTI used in combination with other drugs for HIV treatment and for chronic hepatitis B infection.
124	Levothyroxine Sodium	BCS III	Endocrinology	Thyroid Hormone Replacement	Hypothyroidism, thyroid hormone replacement after thyroidectomy	Synthroid, Euthyrox, Eltroxin	A synthetic thyroid hormone used to treat hypothyroidism, as well as to replace thyroid function after thyroidectomy.
125	Linagliptin	BCS III	Endocrinology	DPP-4 Inhibitor	Type 2 diabetes	Tradjenta	A DPP-4 inhibitor used to help control blood sugar levels in type 2 diabetes by increasing insulin release and decreasing glucose production.
126	Lisinopril	BCS III	Cardiovascular	ACE Inhibitor	Hypertension, heart failure, prevention of kidney damage in diabetes	Zestril, Prinivil	An ACE inhibitor used to treat high blood pressure, heart failure, and to prevent kidney damage in diabetic patients.
127	Metformin	BCS III	Endocrinology	Biguanide	Type 2 diabetes	Glucophage, Riomet	A first-line oral medication for managing type 2 diabetes by improving insulin sensitivity and reducing hepatic glucose production.
128	Methotrexate	BCS III	Oncology, Rheumatology	Antimetabolite	Cancer, rheumatoid arthritis, psoriasis, ectopic pregnancy	Rheumatrex, Trexall	A chemotherapy and immunosuppressive drug used for various cancers, autoimmune diseases like rheumatoid arthritis, and psoriasis.
129	Methyldopa	BCS III	Cardiovascular	Alpha-2 Adrenergic Agonist	Hypertension (particularly during pregnancy)	Aldomet	An antihypertensive medication often used to treat high blood pressure during pregnancy.
130	Mirabegron	BCS III	Urology	Beta-3 Agonist	Overactive bladder	Myrbetriq	A medication that relaxes the bladder muscle to treat overactive bladder symptoms such as urgency and frequency.
131	Neostigmine	BCS III	Neurology, Anesthesia	Cholinesterase Inhibitor	Myasthenia gravis, reversal of neuromuscular blockade after surgery	Prostigmin	A cholinesterase inhibitor used for treating myasthenia gravis and reversing the effects of muscle relaxants during surgery.
132	Olopatadine	BCS III	Ophthalmology, Allergies	Antihistamine, Mast Cell Stabilizer	Allergic conjunctivitis	Patanol, Pataday	An antihistamine used for treating eye allergies, such as allergic conjunctivitis.
133	Pantoprazole	BCS III	Gastroenterology	Proton Pump Inhibitor (PPI)	GERD, peptic ulcers, Zollinger-Ellison syndrome	Protonix	A PPI used to treat acid-related stomach conditions such as GERD and ulcers.
134	Pentosan Polysulfate	BCS III	Urology	Urinary Tract Agent	Interstitial cystitis (painful bladder syndrome)	Elmiron	Used to treat interstitial cystitis, a chronic bladder condition, by providing a protective layer to the bladder.
135	Proguanil	BCS III	Infectious Diseases	Antimalarial	Malaria prevention and treatment	Paludrine	An antimalarial used in combination with other drugs to prevent and treat malaria.
136	Rabeprazole	BCS III	Gastroenterology	Proton Pump Inhibitor (PPI)	GERD, peptic ulcers, Zollinger-Ellison syndrome	AcipHex	A PPI used for treating conditions like GERD, ulcers, and other acid-related disorders.
137	Ranitidine	BCS III	Gastroenterology	H2 Receptor Antagonist	GERD, peptic ulcers, Zollinger-Ellison syndrome	Zantac	An H2 receptor antagonist used to reduce stomach acid, treat GERD, and prevent ulcers.
138	Ribavirin	BCS III	Infectious Diseases	Antiviral	Chronic hepatitis C, respiratory syncytial virus (RSV), and some viral hemorrhagic fevers	Copegus, Rebetol	An antiviral used in combination with other drugs for chronic hepatitis C and some viral infections.
139	Rizatriptan	BCS III	Neurology, Pain Management	Triptan	Acute migraine attacks	Maxalt	A triptan used for the acute treatment of migraines, acting as a serotonin receptor agonist to constrict blood vessels in the brain.
140	Saxagliptin	BCS III	Endocrinology	DPP-4 Inhibitor	Type 2 diabetes	Onglyza	A DPP-4 inhibitor used to improve blood sugar control in patients with type 2 diabetes.
141	Sitagliptin	BCS III	Endocrinology	DPP-4 Inhibitor	Type 2 diabetes	Januvia	A DPP-4 inhibitor used to control blood sugar in type 2 diabetes by enhancing insulin secretion and reducing glucose production.
142	Sofosbuvir	BCS III	Infectious Diseases	Direct-Acting Antiviral	Hepatitis C virus (HCV)	Sovaldi	A direct-acting antiviral used to treat hepatitis C, often in combination with other medications.
143	Tenofovir	BCS III	Infectious Diseases	Nucleoside Reverse Transcriptase Inhibitor (NRTI)	HIV infection, chronic hepatitis B	Viread	An NRTI used for treating HIV and chronic hepatitis B, often combined with other antiviral medications.
144	Thiamine	BCS III	Nutritional, Neurology	Vitamin B1	Thiamine deficiency, Wernicke-Korsakoff syndrome, Beriberi	Thiamine Mononitrate, Betaxin	A vitamin B1 supplement used to prevent and treat thiamine deficiency, which can lead to neurological and cardiovascular issues.
145	Valacyclovir	BCS III	Infectious Diseases	Antiviral	Herpes simplex virus infections, varicella-zoster virus (shingles), cytomegalovirus	Valtrex	An antiviral used to treat infections caused by herpes viruses, including shingles and cold sores.
146	Vibegron	BCS III	Urology, Neurology	Beta-3 Agonist	Overactive bladder	Gemtesa	A beta-3 adrenergic agonist used for treating overactive bladder symptoms such as frequent urination and urgency.
147	Vortioxetine	BCS III	Psychiatry	Serotonin Modulator	Major depressive disorder	Trintellix	A serotonin modulator used to treat major depressive disorder, acting on multiple serotonin receptors and transporters.
148	Zinc Sulfate	BCS III	Nutritional, Dermatology	Mineral Supplement	Zinc deficiency, acne, wound healing	Zinc Sulfate, Zicam	A mineral supplement used to treat zinc deficiency and support immune function, wound healing, and skin health.
149		BCS IV
150		BCS IV
151	Abiraterone	BCS IV	Oncology, Endocrinology	Androgen Biosynthesis Inhibitor	Prostate cancer (metastatic castration-resistant)	Zytiga	An androgen biosynthesis inhibitor used in prostate cancer to decrease androgen levels that fuel tumor growth.
152	Acetazolamide	BCS IV	Neurology, Ophthalmology	Carbonic Anhydrase Inhibitor	Glaucoma, acute mountain sickness, epilepsy, edema	Diamox	A carbonic anhydrase inhibitor used to treat glaucoma, prevent high-altitude sickness, and manage fluid retention and certain types of seizures.
153	Albendazole	BCS IV	Infectious Diseases	Anthelmintic	Parasitic infections (e.g., roundworm, hookworm, tapeworm, and other helminths)	Albenza	An anthelmintic used to treat a variety of parasitic worm infections by inhibiting their ability to absorb glucose.
154	Aprepitant	BCS IV	Oncology, Gastroenterology	Antiemetic	Prevention of chemotherapy-induced nausea and vomiting (CINV)	Emend	A neurokinin-1 receptor antagonist used to prevent nausea and vomiting caused by chemotherapy.
155	Aripiprazole	BCS IV	Psychiatry	Atypical Antipsychotic	Schizophrenia, bipolar disorder, major depressive disorder, autism irritability	Abilify	An atypical antipsychotic used to treat schizophrenia, bipolar disorder, and depression, with a lower risk of movement-related side effects.
156	Avacopan	BCS IV	Rheumatology, Dermatology	Complement Inhibitor	ANCA-associated vasculitis (e.g., granulomatosis with polyangiitis)	Tavneos	A complement C5a receptor inhibitor used for the treatment of autoimmune diseases like vasculitis.
157	Ciprofloxacin	BCS IV	Infectious Diseases	Antibiotic (Fluoroquinolone)	Bacterial infections (e.g., urinary tract infections, respiratory infections)	Cipro	A fluoroquinolone antibiotic used for treating a broad range of bacterial infections, though its use is increasingly limited due to resistance.
158	Digoxin	BCS IV	Cardiovascular	Cardiac Glycoside	Heart failure, atrial fibrillation	Lanoxin	A cardiac glycoside used to treat heart failure and atrial fibrillation by increasing the force of heart contractions and regulating heart rhythm.
159	Docetaxel	BCS IV	Oncology	Taxane	Solid tumors (e.g., breast cancer, non-small cell lung cancer)	Taxotere	A chemotherapy drug used to treat various cancers by inhibiting cell division and slowing tumor growth.
160	Erythromycin	BCS IV	Infectious Diseases	Antibiotic (Macrolide)	Respiratory infections, skin infections, ear infections	Ery-Tab, Erythrocin	A macrolide antibiotic used to treat respiratory infections, skin infections, and more, often used in patients with penicillin allergies.
161	Haloperidol	BCS IV	Psychiatry	Antipsychotic	Schizophrenia, acute psychosis, Tourette syndrome	Haldol	A first-generation antipsychotic used for treating schizophrenia, agitation, and tics associated with Tourette syndrome.
162	Hydrochlorothiazide	BCS IV	Cardiovascular	Thiazide Diuretic	Hypertension, edema (fluid retention)	Microzide	A thiazide diuretic used to treat high blood pressure and edema by promoting urine production to reduce fluid retention.
163	Mesalamine	BCS IV	Gastroenterology	Anti-inflammatory	Inflammatory bowel diseases (e.g., ulcerative colitis, Crohn’s disease)	Asacol, Pentasa	An anti-inflammatory drug used for treating inflammatory bowel diseases by reducing inflammation in the gastrointestinal tract.
164	Paclitaxel	BCS IV	Oncology	Taxane	Solid tumors (e.g., ovarian, breast, lung cancer)	Taxol	A chemotherapy drug used to treat various cancers by preventing cell division.
165	Ponesimod	BCS IV	Cardiovascular, Immunology	Sphingosine 1-Phosphate Receptor Modulator	Multiple sclerosis, autoimmune diseases	Ponvory	A selective sphingosine-1-phosphate receptor modulator used for the treatment of multiple sclerosis to prevent immune cells from attacking the central nervous system.
166	Relugolix	BCS IV	Oncology, Endocrinology	GnRH Antagonist	Prostate cancer, uterine fibroids, endometriosis	Orgovyx	A GnRH antagonist used for hormone-sensitive cancers and conditions by reducing levels of sex hormones.
167	Ritonavir	BCS IV	Infectious Diseases	Protease Inhibitor	HIV infection, HIV-associated opportunistic infections	Norvir	A protease inhibitor used in combination with other antiretroviral drugs for HIV treatment to prevent viral replication.
168	Saquinavir	BCS IV	Infectious Diseases	Protease Inhibitor	HIV infection	Invirase	A protease inhibitor used as part of antiretroviral therapy for HIV infection.
169	Sulfasalazine	BCS IV	Rheumatology, Gastroenterology	Antirheumatic, Antiinflammatory	Rheumatoid arthritis, ulcerative colitis	Azulfidine	An anti-inflammatory and immunosuppressive drug used in rheumatoid arthritis and inflammatory bowel disease.
170	Tivozanib	BCS II	Oncology	VEGF Receptor Tyrosine Kinase Inhibitor	Renal cell carcinoma (kidney cancer)	Fotivda	A VEGF receptor inhibitor used in the treatment of renal cell carcinoma by inhibiting angiogenesis and tumor growth.
171	Verapamil	BCS II	Cardiovascular	Calcium Channel Blocker	Hypertension, angina, arrhythmias	Calan, Isoptin	A calcium channel blocker used to treat high blood pressure, angina, and arrhythmias by relaxing blood vessels and reducing heart workload.
172	Maribavir	BCS III	Infectious Diseases	Antiviral (Cytomegalovirus Inhibitor)	Cytomegalovirus (CMV) infections, especially in immunocompromised patients	Livtencity	An antiviral drug used to treat cytomegalovirus infections, particularly in transplant patients or those with weakened immune systems.
173	Asciminib	BCS I	Oncology	Tyrosine Kinase Inhibitor	Chronic myelogenous leukemia (CML) with BCR-ABL mutations	Scemblix	A targeted therapy for CML that inhibits the ABL1 kinase, a protein associated with cancer cell growth.
174	Maralixibat Chloride	BCS II	Gastroenterology, Hepatology	IBAT Inhibitor	Alagille syndrome, progressive familial intrahepatic cholestasis (PFIC)	Livmarli	An inhibitor of the ileal bile acid transporter (IBAT), used to treat liver diseases like Alagille syndrome and PFIC.
175	Mobocertinib Succinate	BCS IV	Oncology	Epidermal Growth Factor Receptor (EGFR) Inhibitor	Non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations	Exkivity	An EGFR inhibitor used to treat NSCLC with specific mutations, particularly in exon 20 insertion mutations.
176	Belzutifan	BCS IV	Oncology	HIF-2 Alpha Inhibitor	Renal cell carcinoma (RCC) with VHL mutations	Welireg	An inhibitor of HIF-2 alpha used for the treatment of renal cell carcinoma associated with von Hippel-Lindau disease.
177	Odevixibat	BCS IV	Hepatology, Gastroenterology	IBAT Inhibitor	Progressive familial intrahepatic cholestasis (PFIC), Alagille syndrome	Ocaliva	An IBAT inhibitor used to treat cholestatic liver diseases like PFIC and Alagille syndrome by reducing bile acid production.
178	Belumosudil Mesylate	BCS IV	Immunology	Selective PDE4 Inhibitor	Chronic graft-versus-host disease (cGVHD)	Rezurock	A selective phosphodiesterase 4 (PDE4) inhibitor used to treat chronic graft-versus-host disease after stem cell transplantation.
179	Ibrexafungerp Citrate	BCS IV	Infectious Diseases	Antifungal	Invasive fungal infections, including Candida infections	Brexafemme	A novel antifungal used to treat invasive fungal infections, particularly in immunocompromised patients.
180	Infigratinib Phosphate	BCS I	Oncology	FGFR Inhibitor	Cholangiocarcinoma (bile duct cancer) with FGFR2 fusions or rearrangements	Truseltiq	A fibroblast growth factor receptor (FGFR) inhibitor used for the treatment of cholangiocarcinoma with specific FGFR2 mutations.
181	Sotorasib	BCS IV	Oncology	KRAS Inhibitor	Non-small cell lung cancer (NSCLC) with KRAS G12C mutations	Lumakras	A KRAS G12C inhibitor used for the treatment of NSCLC with a specific KRAS mutation.
182	Viloxazine Hydrochloride	BCS IV	Psychiatry	Norepinephrine and Serotonin Reuptake Inhibitor (NRI/SRI)	Attention-deficit/hyperactivity disorder (ADHD)	Qelbree	A norepinephrine and serotonin reuptake inhibitor used to treat ADHD in children and adolescents, with fewer side effects than traditional stimulants.
183	Ponesimod	BCS II	Neurology, Immunology	Sphingosine 1-Phosphate Receptor Modulator	Multiple sclerosis (MS), autoimmune conditions	Ponvory	A selective S1P receptor modulator used to treat multiple sclerosis by preventing immune cells from attacking the central nervous system.
184	Tivozanib Hydrochloride	BCS II & IV	Oncology	VEGF Receptor Tyrosine Kinase Inhibitor	Renal cell carcinoma (RCC), solid tumors	Fotivda	A VEGF receptor inhibitor used for the treatment of RCC, inhibiting angiogenesis and tumor growth.
185	Umbralisib Tosylate	BCS II	Immunology	PI3K-delta Inhibitor	Chronic lymphocytic leukemia (CLL), follicular lymphoma (FL)	Ukoniq	A PI3K-delta inhibitor used to treat certain lymphomas and leukemias by inhibiting cancer cell proliferation and survival.
186	Voclosporin	BCS II	Nephrology	Calcineurin Inhibitor	Lupus nephritis (LN)	Lupkynis	A calcineurin inhibitor used for the treatment of lupus nephritis, reducing inflammation and kidney damage.
187	Vericiguat	BCS II	Cardiovascular	Soluble Guanylate Cyclase (sGC) Stimulator	Chronic heart failure, chronic kidney disease	Verquvo	A sGC stimulator used to treat chronic heart failure by improving the heart’s pumping efficiency and reducing hospitalization.
188	Daridorexant	BCS II	Psychiatry	Dual Orexin Receptor Antagonist	Insomnia	Quviviq	A dual orexin receptor antagonist used to treat insomnia by promoting sleep and helping individuals fall asleep and stay asleep.
189	Abrocitinib	BCS II	Dermatology, Immunology	Janus Kinase (JAK) Inhibitor	Atopic dermatitis (eczema)	Cibinqo	A JAK inhibitor used to treat atopic dermatitis by modulating the immune response that causes inflammation and itching in the skin.
190	Oteseconazole	BCS II	Gynecology	Antifungal	Vulvovaginal candidiasis (yeast infection)	Vivjoa	An antifungal used to treat recurrent vulvovaginal candidiasis (yeast infections) by inhibiting fungal cell wall synthesis.
191	Mavacamten	BCS IV	Cardiovascular	Myosin Inhibitor	Hypertrophic cardiomyopathy (HCM)	Camzyos	A myosin inhibitor used to treat hypertrophic cardiomyopathy by reducing heart muscle stiffness and improving heart function.
192	Futibatinib	BCS II	Oncology	FGFR Inhibitor	Cholangiocarcinoma with FGFR2 mutations	Futibatinib	An FGFR inhibitor used for the treatment of cholangiocarcinoma with FGFR2 gene fusions or rearrangements.
193	Olutasidenib	BCS IV	Oncology	IDH1 Inhibitor	Acute myeloid leukemia (AML) with IDH1 mutations	Idhifa	An IDH1 inhibitor used to treat AML with specific IDH1 mutations, helping to reverse abnormal cancer cell differentiation.
194	Adagrasib	BCS II	Oncology	KRAS Inhibitor	Non-small cell lung cancer (NSCLC) with KRAS G12C mutations	Krazati	A KRAS G12C inhibitor used for treating NSCLC with the KRAS G12C mutation, targeting the cancer-driving protein.
195	ELACESTRANT DIHYDROCHLORIDE	BCS II	Oncology	Estrogen Receptor Antagonist	Estrogen receptor-positive breast cancer	Elacestrant	A selective estrogen receptor degrader (SERD) used for treating estrogen receptor-positive breast cancer.
196	DAPRODUSTAT	BCS IV	Nephrology, Hematology	Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI)	Anemia due to chronic kidney disease (CKD)	Duvroq	A HIF-PHI used to treat anemia associated with CKD by stimulating erythropoiesis (red blood cell production).
197	SPARSENTAN	BCS II	Nephrology, Cardiovascular	Angiotensin II Type 1 Receptor and Endothelin A Receptor Antagonist	Focal segmental glomerulosclerosis (FSGS)	Sparsentan	A dual receptor antagonist used for the treatment of FSGS, a type of kidney disease, to reduce proteinuria and preserve kidney function.
198	OMAVELOXOLONE	BCS IV	Dermatology	Anti-inflammatory	Chronic cutaneous lupus erythematosus (CCLE)	Omaveloxolone	An anti-inflammatory agent used to treat chronic cutaneous lupus erythematosus, targeting inflammation and skin lesions.
199	LENIOLISIB PHOSPHATE	BCS II	Immunology	PI3K Inhibitor	Activated phosphoinositide 3-kinase delta syndrome (APDS)	Lenalidomide	A PI3K delta inhibitor used for treating APDS, a rare immune disorder that leads to immunodeficiency and autoimmune complications.
200	QUIZARTINIB DIHYDROCHLORIDE	BCS II	Oncology	FLT3 Inhibitor	Acute myeloid leukemia (AML) with FLT3 mutations	Quizartinib	A FLT3 inhibitor used to treat AML with FLT3 mutations, inhibiting the receptor involved in leukemogenesis (cancer development).
201	MOMELOTINIB DIHYDROCHLORIDE	BCS II	Oncology	JAK Inhibitor	Myelofibrosis	Momelotinib	A JAK1/2 inhibitor used to treat myelofibrosis, a blood cancer that disrupts bone marrow production and leads to anemia, splenomegaly, and other symptoms.
202	ETRASIMOD ARGININE	BCS II	Immunology	Sphingosine 1-Phosphate Receptor Modulator	Ulcerative colitis, Crohn’s disease, autoimmune conditions	Etrasimod	A selective sphingosine 1-phosphate receptor modulator used to treat autoimmune diseases such as ulcerative colitis and Crohn’s disease.
203	VAMOROLONE	BCS IV	Dermatology, Immunology	Steroid-like Agent	Duchenne muscular dystrophy (DMD)	Vamorolone	A steroid-like drug used to treat DMD, providing anti-inflammatory effects with reduced side effects compared to traditional steroids.
204	FRUQUINTINIB	BCS III	Oncology	VEGF Receptor Tyrosine Kinase Inhibitor	Colorectal cancer, solid tumors	Elunate	A VEGFR inhibitor used in the treatment of metastatic colorectal cancer and other solid tumors by inhibiting angiogenesis.
205	Resmetirom	BCS II	Endocrinology, Hepatology	THR-β Agonist	Nonalcoholic steatohepatitis (NASH) with fibrosis	Resmetirom	A thyroid hormone receptor beta agonist used to treat NASH, a fatty liver disease, by reducing liver fat and inflammation.
206	Aprocitentan	BCS III	Cardiovascular	Endothelin A and B Receptor Antagonist	Resistant hypertension	Aprovel	A dual endothelin receptor antagonist used for treating resistant hypertension by reducing vascular resistance.
207	Vorasidenib	BCS II	Oncology	IDH1/IDH2 Inhibitor	Glioma with IDH1 or IDH2 mutations	Vorasidenib	An IDH1/2 inhibitor used to treat glioma with specific IDH mutations by promoting differentiation of cancer cells.

Biopharmaceutics Classification System (BCS) Classification and Database